The Effect of Pantoprazole on Bone Turnover in Ovariectomized ICR Mice
Year: 2011
Type: article
Abstract: analyzed. Results: Serum osteocalcin concentration was significantly lower in the pantoprazole group compared with the control group (p=0.023). There was no difference in BMD, dry tibia weight, or serum ALP, calcium, phosphorus, or CTX-1 between the two groups. The expression of interleukin (IL)-1β was lower in the pantoprazole group compared with the control group, but not significantly lower (p=0.058). The levels of tumor necrosis factor-α and IL-6 did not differ between the two groups. Conclusions: Pantoprazole, a proton pump inhibitor, decreased serum osteocalcin and suppressed IL-1β expression, suggesting that pantoprazole affects bone formation and resorption in ovariectomized ICR mice. Further studies using larger sample sizes are needed. (Korean J Med 2011;80:56-62)
Language: English
Topic: Bone Metabolism and Diseases
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $500
OpenAlex ID: W1810317047