Red pepper: an aid for gut functional diseases with pain?
Year: 2013
Type: article
Abstract: Functional dyspepsia and irritable bowel syndrome (IBS), as well as other gut functional diseases characterized by vis-ceral hypersensitivity and pain, may render quality of life very poor and account for about 1/3 of visits to gastroenterology departments. They also represent a high cost for society in terms of prescriptions and sick leave. Following an emerging trend some attempts have been made to pharmacologically decrease visceral hypersensitivity with a number of drugs, but with little clinical success. In recent years, however, visceral hypersensitivity and pain have been ascribed in most cases to hyperactivity of transient receptor potential vanilloid 1 (TRPV1) nociceptive fibers, that transfer the pain sensations to central nervous system (CNS), which are activated by noxious thermal, mechanical or chemical stimuli and these may be a new target for treatment of visceral pain [1].
Source: Europe PMC (PubMed Central)
Author: Mauro Bortolotti
Institution: University of Bologna
Language: English
Subfield: Gastroenterology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1816285026