Selective inhibition of herpes simplex virus by 5-amino-2,5-dideoxy-5-iodouridine
Year: 1975
Type: article
Abstract: 5-Amino-2,5-dideoxy-5-iodouridine, a nel thymidine analogue, is a potent inhibitor of herpes simplex virus type 1 replication. In contrast to most other nucleoside analogues which possess antiviral activity, 5-amino-2,5-dideoxy-5-iodouridine exhibits little, if any, cellular toxicity. Preliminary evidence suggests that 5-amino-2,5-dideoxy-5-iodouridine selectively inhibits viral-specific DNA synthesis.
Source: Journal of Virology
Authors: Y C Cheng, B Goz, J P Neenan, D C Ward, W H Prusoff
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1816515376