Thyroid hormone metabolism: importance of deiodination, conjugation and side chain modification
Year: 1992
Type: dissertation
Abstract: Extrathyroidal deiodination of T4 is the most important route for production of bioactive\nT3. This occurs predominantly in the liver, catalyzed by the microsomal type I deiodinase,\nwhich is also responsible for most of the degradation of the inactive rT 3. The liver is\nfurthermore essential for the conjugation of iodothyronines with sulfate and glucuronic\nacid. This thesis deals with the connection between the various biochemical pathways of\nthyroid hormone metabolism. A better understanding of those metabolic routes involved\nin the regulation ofT 3 bioavailability helps to clarify the changes in the thyroid hormone\neconomy induced by pathophysiological conditions. The successive Chapters II-VIII\nroughly reflect the chronological order of my experimental studies
Author: Marja Rutgers
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1816739003