Work

Potentiative effects of standardized extract of Centella asiatica on vinblastine-induced cell death

Year: 2010

Type: article

Abstract: The purpose of this study was to investigate the influence of a standardized extractfrom Centella asiatica (ECa-233) and asiaticoside (ATS) on vinblastine (VBL)-inducedcytotoxicity in porcine renal epithelial cell line (LLC-PK1) and its MDR1-gene-transfectedepithelial cell line (LLC-MDR1). The cells were co-treated with VBL (at variousconcentrations) and either ECa-233 or ATS for 72 hr prior to determination of cell viabilitywith the MTT assay. Our results showed that the noncytotoxic ECa-233 and ATS couldenhance the cytotoxicity of VBL in both cell types. It was likely that both ECa-233 and ATSwere able to inhibit the function of P-glycoprotein, a known membrane efflux pump of VBLand might be useful in cancer chemotherapy.

Source: Journal of Basic and Applied Pharmacology

Authors: Narumol Ruamsuk, Thitima Pengsuparp, Suree Jianmongkol

Institution: Chulalongkorn University

Language: Thai

Topic: Drug Transport and Resistance Mechanisms

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Chulalongkorn University

OpenAlex ID: W1818544829

FWCI:

Cites: 5

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Related to: 10