Work

T-cell cytokine responses in human infection with Mycobacterium tuberculosis

Year: 1995

Type: article

Abstract: Compared with healthy tuberculin reactors, Mycobacterium tuberculosis-stimulated peripheral blood mononuclear cells from tuberculosis patients had diminished production and mRNA expression of the Th1 cytokines gamma interferon and interleukin 2 (IL-2), with no change in production and mRNA expression for the Th2 cytokines IL-4, IL-10, and IL-13. These results were confirmed by evaluation of T cells and CD4+ cells. At the level of systemic T cells, development of tuberculosis is associated with diminished Th1 but not enhanced Th2 responses.

Source: Infection and Immunity

DOI: 10.1128/iai.63.8.3231-3234.1995

Authors: M Zhang, Y Lin, D V Iyer, J Gong, J S Abrams, P F Barnes

Institution: University of Southern California

Language: English

Topic: Tuberculosis Research and Epidemiology

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute of Allergy and Infectious Diseases, National Center for Research Resources