Role of bile and bile salts on cyclosporine absorption in dogs.
Year: 1987
Type: article
Abstract: REVIOUS STUDIES in liver transplantpatients indicate an increase in the trough cyclosporine (CsA) concentrations subsequent to the removal or clamping of the T tube.I • 2 Since less than 1 % of an administered dose of CsA is excreted as the unchanged drug, enterohepatic recirculation is not responsible for such an observation.3 It is likely that improved bile flow into the gut secondary to the clamping process increases CsA absorption and therefore the trough concentrations.Our objective was to determine the role of bile and bile salts on the absorption of CsA in dogs.
Source: PubMed
Authors: B G Ericzon, S Todo, S Lynch, I Kam, R J Ptachcinski, G J Burckart, D H Van Thiel, T E Starzl, R Venkataramanan
Institution: University of Pittsburgh
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1821897359