Year: 2025
Type: article
Study design: Observational Study
Abstract: Cardiovascular diseases remain a leading cause of global mortality and morbidity, with dyslipidemia recognised as its key risk factor.While overt clinical symptoms often manifest later in life, subclinical vascular and myocardial changes may begin in young adulthood but remain underexplored.Noninvasive cardiovascular measures provide valuable tools for detecting such early alterations.This study aimed to examine the effects of dyslipidemia on cardiovascular markers among young adult males population.This cross-sectional study included 83 male participants aged 20-40 years.Participants underwent lipid profiling, pulse wave velocity (PWV) measurement, and echocardiographic assessment of left ventricular and diastolic function.Dyslipidemia was defined as total cholesterol >5.2 mmol/L.Comparative analyses were performed to assess the difference between dyslipidemic and normolipidemic participants and correlation analyses were used to examine the association between dyslipidemia and cardiovascular markers.Dyslipidemic participants were significantly older than normolipidemic participants [35 (29-37) years old vs 31 (26-35) years old, p=0.023].After adjusting for age, dyslipidemia was associated with a significant reduction in left ventricular ejection fraction (LVEF) (β = -3.24,95% CI:-5.79 to -0.69, p=0.013).A significant negative correlation was also found between total cholesterol and LVEF (r = -0.254,p=0.023).No significant difference was observed between groups for PWV [dyslipidemic 6.50 (6.10-7.40m/s) vs normolipidemic 6.35 (5.70-7.42m/s)].In young adult males, dyslipidemia is associated with reduced LVEF, indicating an adverse effect of dyslipidemia on myocardial function beginning early in life, underscoring the potential importance of early lipid management.
Source: Medicine & health
Author: Rebecca Wilson
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Award: G5826520363
OpenAlex ID: W1822379966