Work

Tumor-Infiltrating Dendritic Cells in Cancer Pathogenesis

Year: 2015

Type: review

Abstract: Dendritic cells (DCs) play a pivotal role in the tumor microenvironment, which is known to affect disease progression in many human malignancies. Infiltration by mature, active DCs into the tumors confers an increase in immune activation and recruitment of disease-fighting immune effector cells and pathways. DCs are the preferential target of infiltrating T cells. However, tumor cells have means of suppressing DC function or of altering the tumor microenvironment in such a way that immune-suppressive DCs are recruited. Advances in understanding these changes have led to promising developments in cancer-therapeutic strategies targeting tumor-infiltrating DCs to subdue their immunosuppressive functions and enhance their immune-stimulatory capacity.

Source: The Journal of Immunology

DOI: 10.4049/jimmunol.1403134

Authors: Jo Marie Tran Janco, Purushottam Lamichhane, Lavakumar Karyampudi, Keith L Knutson

Institutions: Mayo Clinic, Vaccine & Gene Therapy Institute of Florida

Language: English

Topic: Immunotherapy and Immune Responses

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Cancer Institute