Work

Medical genetics: 1. Clinical teratology in the age of genomics.

Year: 2002

Type: article

Abstract: Teratogenic exposures are those that can cause an embryo or fetus to develop abnormally. Several factors determine whether an agent is teratogenic, including the gestational timing of the exposure, as well as the dose, route and nature of the agent itself. We review the general concepts of teratogenesis, as well as known genetic susceptibilities to teratogenic effects, with a special focus on antiepileptic drugs. We discuss general principles of risk counselling and risk reduction, and we describe several long-known teratogens, as well as several exposures recognized only recently to have teratogenic potential.

Source: Europe PMC (PubMed Central)

Authors: Janine E Polifka, J M Friedman

Institution: University of Washington

Language: English

Topic: Pharmacological Effects and Toxicity Studies

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1824421054

FWCI: 3.44

Cites: 93

Cited by: 63

Related to: 10