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Discovery of microbial natural products by activation of silent biosynthetic gene clusters

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Year: 2015
Type: review
Source: Nature Reviews Microbiology
DOI: 10.1038/nrmicro3496
Authors: Peter J. Rutledge, Gregory L. Challis
Institutions: The University of Sydney, University of Warwick
Language: English

Topic: Microbial Natural Products and Biosynthesis
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences

Open Access status: closed

Funders: Royal Society, Research Councils UK, Royal Society of Chemistry, University of Warwick, Directorate for Biological Sciences, Medical Research Council, Biotechnology and Biological Sciences Research Council
Awards: EVOBIOTIC: Capturing the natural antibiotic'ome: Developing Nature's EVOlved AntiBIOTIC, Exploitation of Burkholderia bacteria as novel antibiotic producers using a genome mining approach, Warwick Integrative Synthetic Biology Centre, Exploiting natural product assembly line genomics and synthetic biology for discovery and optimisation of novel agrochemicals, Exploiting microbial genomics and synthetic biology for discovery of novel antibiotics, G8897364305
OpenAlex ID: W1827213771
FWCI: 6.648
Cites: 146
Cited by: 1,043
Related to: 10
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