Work

Synthesis of Pyrrolidines and Pyrroles by Tandem Amination/Cyanation/Alkylation and Amination/Oxidation Sequences

Year: 2014

Type: article

Abstract: Copper‐catalyzed three‐component tandem amination/cyanation/alkylation of the primary‐amine‐tethered alkynes 1 gave α‐CN‐substituted pyrrolidines 6 in good yields and regioselectivities. In addition, silver‐mediated tandem amination/oxidation of the secondary‐amine‐tethered alkynes 7 produced functionalized pyrroles 8 in good yields. All reactions were conducted in one pot without any protection/deprotection steps.

Source: European Journal of Organic Chemistry

DOI: 10.1002/ejoc.201402748

Authors: Junbin Han, Zhichao Lu, Gerald B. Hammond, Bo Xu

Institution: University of Louisville

Language: English

Topic: Synthesis and Characterization of Pyrroles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Award: Transition metal catalyzed construction of ring systems