GABA, serotonin, muscarinic receptors - their second messengers and transcription factors functional regulation in the brain regions of hypoxic neonatal rats: Resuscitation with glucose, oxygen and epinephrine
Year: 2010
Type: dissertation
Abstract: The present study was designed to investigate the protective effect of\nglucose, oxygen and epinephrine resuscitation on impairment in the functional role\nof GABAergic, serotonergic, muscarinic receptors, PLC, BAX, SOD, CAT and\nGPx expression in the brain regions of hypoxia induced neonatal rats. Also, the\nrole of hormones - Triiodothyronine (T3) and insulin, second messengers –\ncAMP, cGMP and IP3 and transcription factors – HIF and CREB in the regulation\nof neonatal hypoxia and its resuscitation methods were studied. Behavioural\nstudies were conducted to evaluate the motor function and cognitive deficit in one\nmonth old control and experimental rats. The efficient and timely supplementation\nof glucose plays a crucial role in correcting the molecular changes due to hypoxia,\noxygen and epinephrine. The sequence of glucose, epinephrine and oxygen\nadministration at the molecular level is an important aspect of the study. The\nadditive neuronal damage effect due to oxygen and epinephrine treatment is\nanother important observation. The corrective measures by initial supply of\nglucose to hypoxic neonatal rats showed from the molecular study when brought\nto practice will lead to healthy intellectual capacity during the later developmental\nstages, which has immense clinical significance in neonatal care.
Authors: T.R. Anju, C.S. Paulose
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1827771561