Putamen–midbrain functional connectivity is related to striatal dopamine transporter availability in patients with Lewy body diseases
Year: 2015
Type: article
Study design: Observational Study
Abstract: Prior work has shown that functional connectivity between the midbrain and putamen is altered in patients with impairments in the dopamine system. This study examines whether individual differences in midbrain-striatal connectivity are proportional to the integrity of the dopamine system in patients with nigrostriatal dopamine loss (Parkinson's disease and dementia with Lewy bodies). We assessed functional connectivity of the putamen during resting state fMRI and dopamine transporter (DAT) availability in the striatum using 11C-Altropane PET in twenty patients. In line with the hypothesis that functional connectivity between the midbrain and the putamen reflects the integrity of the dopaminergic neurotransmitter system, putamen-midbrain functional connectivity was significantly correlated with striatal DAT availability even after stringent control for effects of head motion. DAT availability did not relate to functional connectivity between the caudate and thalamus/prefrontal areas. As such, resting state functional connectivity in the midbrain-striatal pathway may provide a useful indicator of underlying pathology in patients with nigrostriatal dopamine loss.
Source: NeuroImage Clinical
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,490
Funders: Michael J. Fox Foundation for Parkinson's Research, Alzheimer's Association, Massachusetts General Hospital, European Commission, Centre d'Imagerie BioMédicale, National Institutes of Health, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, National Institute on Aging, National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Center for Research Resources
Awards: PET imaging of hyperphosphorylated tau differentiates PSP and CBD from PD, G1173778324, G1185609304, G1360098495, G1778344677, G2227408383, G3171611343, National Alzheimer's Coordinating Center, G3549079774, G393103480, G5557224331, Computeserver Structural &Functional Image Analysis, Massachusetts Alzheimer's Disease Research Center, Center for Functional Imaging Technologies, A 3.0 Tesla MRI System in a Neuroscience ICU, G868551019, A Storage Area Network for Structural and Functional Image Analysis, G9000030076, G9000208643, Silicon Graphics Prism Extreme 128P/1TB, G984581029
OpenAlex ID: W1828063505