Work

Expression of normal myeloid-associated antigens by acute leukemia cells

Year: 1986

Type: article

Abstract: Monoclonal antibodies that react with hematopoietic cells and their precursors in a stage and lineage restricted fashion were used in indirect immunofluorescence assays to examine leukemic cells from 105 pediatric age patients. The differentiative states of blasts from 42 patients with acute nonlymphocytic leukemia (ANLL) were defined by these antibodies. When these were compared to their morphologic and histochemical levels of differentiation as defined by the French-American-British (FAB) classification, no direct relationship was found. The reactivity of these antibodies with leukemic cells from 63 patients with acute lymphocytic leukemiA (ALL) was also investigated, and the usefulness of these antibodies in distinguishing leukemias of myeloid from those of lymphoid origin was demonstrated.

Source: Blood

DOI: 10.1182/blood.v67.4.1048.1048

Authors: PA Dinndorf, RG Andrews, D Benjamin, D Ridgway, L Wolff, ID Bernstein

Institutions: Fred Hutch Cancer Center, Oregon Health & Science University, University of Washington, Doernbecher Children's Hospital

Language: English

Topic: Acute Myeloid Leukemia Research

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Cancer Institute