Short Communication: The Relationship Between Mitochondrial Dysfunction and Insulin Resistance in HIV-Infected Children Receiving Antiretroviral Therapy
Year: 2013
Type: article
Study design: Observational Study
Abstract: Mitochondrial abnormalities may lead to metabolic complications in HIV-infected children who have been receiving long-term antiretroviral treatment. We conducted a matched, case-control study comparing 21 HIV-infected children with insulin resistance (cases) to 21 HIV-infected children without insulin resistance (controls) to assess differences in mitochondrial DNA (mtDNA) copies/cell and oxidative phosphorylation NADH dehydrogenase (C1) and cytochrome c oxidase (C4) enzyme activities in peripheral blood mononuclear cells. MtDNA copies/cell tended to be lower in cases, and fasting serum glucose levels were inversely and significantly correlated with C1 enzyme activity, more so in cases. Larger pediatric studies should evaluate mitochondrial etiologies of insulin resistance and determine the role of antiretroviral therapies or HIV infection on mitochondrial dysfunction.
Language: English
Subfield: Emergency Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: U.S. Department of Health and Human Services, University of Miami, Bunning Food Allergy Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Harvard University, St. Jude Children's Research Hospital, Tulane University, Saint Christopher's Hospital for Children, National Institutes of Health, University of California, San Diego, University of Colorado Denver, National Institute on Alcohol Abuse and Alcoholism, National Institute of Mental Health, National Institute on Drug Abuse, National Institute on Deafness and Other Communication Disorders, National Institute of Nursing Research, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Child Health and Human Development, National Institute of Dental and Craniofacial Research, Office of AIDS Research, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1121950248, G1526836824, G1579334765, G2106924369, G3215336396, G3723406741, Mitochondrial Determinants of Metabolic Disease in HIV-Infected Children, Pediatric HIV/AIDS Cohort Study (PHACS) Coordinating Center (CC) (U01), The Role of Mitochondrial Toxicity in Metabolic Complications of Pediatric HIV, Colorado Clinical and Translational Sciences Institute, Pediatric HIV/AIDS Cohort Study (PHACS): Data and Operations Center (DOC)., G8402651462, G8582443069
OpenAlex ID: W1832507556