Year: 2015
Type: article
Abstract: BACKGROUND: Statin intolerance is often due to myalgias. Severe vitamin D deficiency is characterized by musculoskeletal pain. We hypothesized that statin-intolerance is associated with vitamin D deficiency. OBJECTIVES: To determine whether there is an association between statin-intolerance and vitamin D deficiency in a retrospective observational analysis. METHODS: We evaluated 20 female patients with prior myalgia-related daily dose statin intolerance on an alternative day statin dosing protocol of twice weekly for 4 weeks followed by advancement to daily dosing, as tolerated. Fasting baseline and follow-up lipid and 25-hydroxy-vitamin D (25-OHD) levels were obtained by chart review. RESULTS: The group median age was 61 ± 13 years old and BMI was 27 ± 7 kg/m(2). Women who remained on alternative day statin dosing (n = 16) compared to women on daily dosing (n = 4) had a significantly lower group mean 25-OHD (mean 29 ± 11.23 vs. 47.5 ± 23.53 ng/ml p = 0.0307 respectively). CONCLUSIONS: In women with prior myalgia-related statin intolerance, vitamin D levels were significantly lower in women who remained on alternative day dosing compared to those who were tolerant of daily dosing.
Source: BMC Research Notes
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,690
Funders: Deutsches Krebsforschungszentrum, Society for Women’s Health Research, Ladies Hospital Aid Society, Cedars-Sinai Medical Center, Qmed, National Institutes of Health, U.S. Public Health Service, National Institute on Aging, National Heart, Lung, and Blood Institute, National Center for Research Resources, National Center for Advancing Translational Sciences
Awards: G1120375403, G1134269671, G1369121676, G1438650436, G1539922453, G1710551794, G1764559527, Together: Transforming and Translating Discovery to Improve Health, G2026361351, G2058569893, Behavioral Medicine and Cardiovascular Research Training, EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR, G276921238, G2933049717, EVAL OF ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CTR, ISCHEMIC HEART DISEASE IN WOMEN-CLINICAL CENTER, G3206908124, G327285978, UCLA Clinical and Translational Science Institute, G3745418417, G3751788867, ISCHEMIC HEART DISEASE IN WOMEN--CLINICAL CENTER, G3821788555, G3914182225, UF Clinical and Translational Science Award, G4144345384, G430456586, G4464624970, G453528718, G461158050, Cardiovascular Events in Women's Ischemia Syndrome Evaluation, G6621596241, Women's Ischemia Syndrome Evaluation (WISE) Coronary Vascular Dysfunction, G7007650866, General Clinical Research Center, G7636702871, G7781681247, G7824414775, G7884066925, G8399618014, G8664061136, Cardiac Autonomic Function in Women
OpenAlex ID: W1833931710