Work

Histamine reduces ZO-1 tight-junction protein expression in cultured retinal microvascular endothelial cells

Year: 1996

Type: article

Abstract: We examined ZO-1 protein content in cultured retinal vascular endothelial cells to test the hypothesis that histamine alters tight-junction-protein expression. Histamine (10(-9) -10(-4) M) causes a reversible concentration-dependent reduction of ZO-1 protein content, mediated by both H1 and H2 receptors. Histamine reduces ZO-1 expression within the time associated with increased paracellular permeability. Tight-junction-protein alterations may be a novel explanation for the mechanism by which vasoactive agents increase microvascular permeability.

Source: Biochemical Journal

DOI: 10.1042/bj3200717

Authors: Thomas W. GARDNER, Treena LESHER, Sonny KHIN, Cuong VU, Alistair J. BARBER, William A. BRENNAN

Institution: Pennsylvania State University

Language: English

Topic: Barrier Structure and Function Studies

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze