Year: 2013
Type: dissertation
Study design: Observational Study
Abstract: Child undernutrition and diarrhea are two public health concerns in Madagascar. Microsporidias, cryptosporidia, Isospora belli and Cyclospora cayetanensis are pathogens involved in diarheas of the immunosuppressed host. Undernutrition inducing a relative immunosuppression, the aim of this work was to explore digestive carriage of these opportunistic pathogens in diarrheal undernourished child. First, a retrospective study was conducted in a rural area near Moramanga and compared digestive carriage of these pathogens in stunted and well nourished diarrheal children. A second one was managed in a pediatric hospital of Antananarivo on diarrheal children with severe acute malnutrition. These two studies confirmed presence of these opportunistic pathogens in Madagascar and their high frequency in children. Nutritional and environmental factors had been associated to digestive carriage in the retrospective study. Severe stunting (i. e. Z-score (height/age)< -3) was found correlated to microsporidias' carriage. The study conducted in Antananarivo pointed out several carriages of opportunistic parasites, but also possible yeasts digestive colonizations. Validations of these results by molecular biology are in progress, therefore they could participate to improve guidelines for severe acute malnourished diarrheal chidren care and to improve the fight against diarrhea and undernutrition of the child in Madagascar.
Source: HAL
Author: Guillaume Roux
Institution: Université Grenoble Alpes
Language: French
Subfield: Parasitology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1837887190