Work

Is it safe to switch from stavudine to zidovudine after developing symptomatic hyperlactatemia?

Year: 2008

Type: article

Abstract: INTRODUCTION: In resource limited settings patients on antiretroviral treatment who develop stavudine induced hyperlactatemia are often switched to zidovudine on the basis of published studies that demonstrate that this agent can be a safe alternative. CASE REPORT: We describe here a case of a 60 year old female that experienced a relapse of symptomatic hyperlactatemia after being switched from stavudine to zidovudine and how the case was managed at the Infectious Diseases Institute, Kampala, Uganda. DISCUSSION: This case shows that switching to zidovudine potentially can lead to a hyperlactatemia relapse. Therefore we recommend close follow up for patients that are switched from stavudine to zidovudine and, in case lactate measurement is not possible, free programs should provide safer drugs such as abacavir and tenofovir for patients that develop hyperlactatemia.

Source: PubMed

Authors: Barbara Castelnuovo, Agnes Nanyonjo, Moses Kamya, Ponsiano Ocama

Institution: Infectious Diseases Institute

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W183837148

FWCI: 0.402

Cites: 8

Cited by: 3

Related to: 20