Neurodevelopmental impairment, dopamine sensitisation, and social adversity in schizophrenia.
Year: 2002
Type: article
Abstract: During the early 1980s, the view emerged that schizophrenia had a significant developmental component (1-4), and subsequently the 'neurodevelopmental hypothesis' became the dominant model in schizophrenia research. However, while few now doubt that neurodevelopmental disturbance plays an important role in schizophrenia, it is increasingly clear that the original simple 'doomed from the womb' model offers only a partial explanation for the disorder. Consequently, attention has recently turned to a) whether the process of aberrant development is an exclusively biological one or whether there is also a psychosocial component; and b) what causes the onset of psychosis. There is increasing evidence that dopamine sensitisation provides the link between early developmental deviance and the vulnerability of the preschizophrenic individual to certain stressors in the social environment.
Source: Europe PMC (PubMed Central)
Authors: Robin M Murray, Colm McDonald, Elvira Bramon
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1839016994