Clinical and Biochemical Characteristics in Women With Polycystic Ovarian Syndrome in the Region of Pollog, Republic of Macedonia
Year: 2014
Type: article
Study design: Observational Study
Abstract: Polycystic ovary syndrome (PCOS) is a common endocrine disorder and is a major cause of an ovulatory infertility. The main objective is to estimate the prevalence of PCOS in the region of Pollog, Republic of Macedonia and to assess some clinical and biochemical parameters in patients with PCOS in comparison with normal women as control. Rotterdam criteria is used to evaluate 70 women diagnosed with PCOS, compared to 30 age matched controls to assess the clinical and biochemical abnormalities that occur in PCOS patients. All statistical analysis is done using SPSS (version 19.0). A P-value < 0.05 is considered statistically significant. Mean age in PCOS group is 25.11 ± 3.32, and 25.10 ± 3.91 in the control group. BMI of the women with PCOS is significantly higher than in the control group. Menstrual cycle abnormalities are observed in 71.4 % of PCOS patients, and ultrasonographic appearance of polycystic ovaries is reported for all PCOS cases. Hirsutism (FG 8-9) is present in 42.9 %, hirsutism (FG 10-14) in 50 % and 7.1 % showed hirsutism (FG>15). We recorded significantly higher serum levels of luteinizing hormone (LH), total testosterone (TT), and insulin, while the serum levels of sex hormone binding globuline (SHBG) and follicular stimulating hormone (FSH) are significantly lower than in the control group. By analyzing the clinical and biochemical characteristics of our studied population of patients with PCOS, we can conclude that the majority of our patients expressed all three diagnostic features of PCOS (hyperandrogenism, menstrual abnormalities, and ultrasound findings of polycystic ovaries).
Authors: Arian Alili, Edita A. Idrizi
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1839923944