Work

Role in vivo for gamma interferon in control of pneumonia caused by Chlamydia trachomatis in mice

Year: 1988

Type: article

Abstract: In a model of pneumonia caused by murine Chlamydia trachomatis, depletion experiments with monoclonal antibody to gamma interferon (IFN-gamma) made mice more susceptible. Repletion experiments giving exogenous recombinant murine IFN-gamma were not consistently protective. IFN-gamma may be necessary but not sufficient in host defense against the organism.

Source: Infection and Immunity

DOI: 10.1128/iai.56.11.3004-3006.1988

Authors: D M Williams, G I Byrne, B Grubbs, T J Marshal, J Schachter

Institutions: The University of Texas at San Antonio Health Science Center, Audie L. Murphy Memorial VA Hospital

Language: English

Topic: Reproductive tract infections research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute of Allergy and Infectious Diseases