Work

Profiling metabolic remodeling in PP2Acα deficiency and chronic pressure overload mouse hearts

Year: 2015

Type: article

Abstract: Our understanding of how metabolic switches occur in the failing heart is still limited. Here, we report the emblematic pattern of metabolic alternations in two different mouse models. PP2Acα deficient hearts exhibited a dramatic decrease in the levels of mRNA encoding for transporters and enzymes involved in glucose utilization, which compensated by higher expression levels of genes controlling fatty acid utilization. These features were partly reproduced in cultured PP2Acα KD cardiomyocytes. Equivalently, a decrease in the expression of most of the transporters and enzymes controlling both glucose and fatty acid metabolism were observed in TAC model.

Source: FEBS Letters

DOI: 10.1016/j.febslet.2015.10.016