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The Mechanisms of Generation, Recognition, and Erasure of DNA 5-Methylcytosine and Thymine Oxidations

Year: 2015
Type: review
Abstract: One of the most fundamental questions in the control of gene expression in mammals is how the patterns of epigenetic modifications of DNA are generated, recognized, and erased. This includes covalent cytosine methylation of DNA and its associated oxidation states. An array of AdoMet-dependent methyltransferases, Fe(II)- and α-ketoglutarate-dependent dioxygenases, base excision glycosylases, and sequence-specific transcription factors is responsible for changing, maintaining, and interpreting the modification status of specific regions of chromatin. This review focuses on recent developments in characterizing the functional and structural links between the modification status of two DNA bases 5-methylcytosine and thymine (5-methyluracil).
DOI: 10.1074/jbc.r115.656884
Language: English
Open Access status: hybrid
Estimated APC paid: $3,430
Funders: Emory University, Georgia Research Alliance, National Institutes of Health, Winship Cancer Institute, National Cancer Institute, National Institute of General Medical Sciences, National Institute of Diabetes and Digestive and Kidney Diseases
Awards: G267171126, G2767106131, G322599019, DNA Methylation: Structures, Functions and Regulation, Defining Genomic Signatures for Aberrant DNA Methylation in Human Cancers, G4103361985, Cell therapy for diabetic peripheral neurovascular complications, G5310809001, G5562084361, G6680957141, G8046699131, Novel 5-methylcytosine Oxidases, Genesis and Consequences of Aberrant DNA Methylation, G9000080494, Winship Cancer Institute Cancer Center Support Grant
OpenAlex ID: W1841647688
FWCI: 0.553
Cites: 102
Cited by: 40
Related to: 10