Year: 2014
Type: article
Study design: Observational Study
Abstract: Several modifiable lifestyle factors, including smoking, alcohol, certain dietary factors and weight are independently associated with gastric cancer (GC); however, their combined impact on GC risk is unknown. We constructed a healthy lifestyle index to investigate the joint influence of these behaviors on GC risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The analysis included 461,550 participants (662 first incident GC cases) with a mean follow-up of 11.4 years. A healthy lifestyle index was constructed, assigning 1 point for each healthy behavior related to smoking status, alcohol consumption and diet quality (represented by the Mediterranean diet) for assessing overall GC and also body mass index for cardia GC and 0 points otherwise. Risk of GC was calculated using Cox proportional hazards regression models while adjusting for relevant confounders. The highest versus lowest score in the healthy lifestyle index was associated with a significant lower risk of GC, by 51% overall (HR 0.49 95% CI 0.35, 0.70), by 77% for cardia GC (HR 0.23 95% CI 0.08, 0.68) and by 47% for noncardia GC (HR 0.53 (95% CI 0.32, 0.87), p-trends<0.001. Population attributable risk calculations showed that 18.8% of all GC and 62.4% of cardia GC cases could have been prevented if participants in this population had followed the healthy lifestyle behaviors of this index. Adopting several healthy lifestyle behaviors including not smoking, limiting alcohol consumption, eating a healthy diet and maintaining a normal weight is associated with a large decreased risk of GC.
Source: International Journal of Cancer
DOI: 10.1002/ijc.29411
Authors: G. Buckland, N. Travier, J.M. Huerta, H.Bas Bueno-de-Mesquita, P.D. Siersema, G. Skeie, E. Weiderpass, D. Engeset, U. Ericson, B. Ohlsson, A. Agudo, I. Romieu, P. Ferrari, H. Freisling, S. Colorado-Yohar, K. Li, R. Kaaks, V. Pala, A.J. Cross, E. Riboli, A. Trichopoulou, P. Lagiou, C. Bamia, M.C. Boutron-Ruault, G. Fagherazzi, L. Dartois, A.M. May, P.H. Peeters, S. Panico, M. Johansson, B. Wallner, D. Palli, T.J. Key, K.T. Khaw, E. Ardanaz, K. Overvad, A. Tjønneland, M. Dorronsoro, M.J. Sánchez, J.R. Quirós, A. Naccarati, R. Tumino, H. Boeing, C.A. Gonzalez
Institutions: Institut d'Investigació Biomédica de Bellvitge, Institut Català d'Oncologia, Centro de Investigación Biomédica en Red, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, University Medical Center Utrecht, National Institute for Public Health and the Environment, Imperial College London, UiT The Arctic University of Norway, Karolinska Institutet, Cancer Registry of Norway, Folkhälsans Forskningscentrum, Lund University, Skåne University Hospital, Centre international de recherche sur le cancer, German Cancer Research Center, Fondazione IRCCS Istituto Nazionale dei Tumori, Academy of Athens, Hellenic Health Foundation, Harvard University, National and Kapodistrian University of Athens, Université Paris-Sud, Inserm, Centre de recherche en Epidémiologie et Santé des Populations, Federico II University Hospital, University of Naples Federico II, Umeå University, Istituto per lo Studio e la Prevenzione Oncologica, University of Oxford, University of Cambridge, MRC Epidemiology Unit, Aarhus University, Danish Cancer Society, Biogipuzkoa Health Research Institute, Instituto de Investigación Biosanitaria de Granada, Andalusian School of Public Health, Italian institute for Genomic Medicine, German Institute of Human Nutrition
Language: English
Topic: Nutritional Studies and Diet
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: World Health Organization, Cancer Research UK, National Institute for Health and Care Research, European Commission, Bundesministerium für Bildung und Forschung, Cancerfonden, NordForsk, Associazione Italiana per la Ricerca sul Cancro, Norges Forskningsråd, Deutsche Krebshilfe, Hellenic Health Foundation, Medical Research Council, World Cancer Research Fund, Instituto de Salud Carlos III
OpenAlex ID: W1842019566