Year: 1982
Type: article
Abstract: We examined the migratory properties of the mouse serum protein responsible for specific neutralization of the endogenous mouse xenotropic type C virus and demonstrated that this neutralizing factor can be transferred from mouse lipoproteins to human and to nonreactive mouse lipoproteins. After acceptance of this activity by these lipoproteins, it could be back-transferred to human and to mouse lipoproteins. This result was compatible with equilibrium binding of the responsible proteins by several classes of lipoproteins. The best expression of the transferred activity occurred with human chylomicrons. Small quantities of neutralizing factor which exist in free dispersion in serum were also detected by mixing the p greater than 1.21 g/ml density fraction of mouse serum with human chylomicrons; antiviral activity was subsequently found associated with the human lipoproteins. This result reflects the potentiation of antiviral activity of the protein in a lipoprotein environment. These observations offer a useful approach for the eventual purification and characterization of the neutralizing factor.
Source: Journal of Virology
Authors: J A Levy, J Dimpfl, D Hardman, J P Kane
Language: English
Topic: HIV Research and Treatment
Subfield: Virology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1842462284