Work

Structural-functional relationships in experimentally induced brain damage

Year: 1988

Type: book-chapter

Abstract: The purpose of this chapter is to introduce some of the themes of neuroteratology by tracing its historical connections to the study of somatic malformations. This is most easily done by discussing studies of general teratogens, that is, ones which affect all cells. Antimitotic agents are a classic example of teratogens with general effects. The availability of antisera to growth hormone, growth hormone releasing factor (GHRF) and somatostatin, the fact that the feedback loops of this system do not automatically adjust hormone levels to normal, and the fact that the target tissue includes most or all parts of the body. The pattern of growth in the absence of growth hormone is distinctive. In the mouse and rat, growthhormone-deficient animals begin to diverge from normal animals after about two weeks of postnatal life, as seen in mutants such as the dwarf mouse, which lacks somatotropes. One teratological syndrome that appears to exhibit this pattern of growth is fetal alcohol syndrome (FAS).

Source: Progress in brain research

DOI: 10.1016/s0079-6123(08)60514-2

Author: Patricia M. Rodier

Institutions: University of Rochester Medicine, University of Rochester

Language: English

Topic: Pharmacological Effects and Toxicity Studies

Subfield: Pediatrics, Perinatology and Child Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of Neurological Disorders and Stroke