Year: 2015
Type: article
Abstract: Since their original discovery in 1948, tetracycline antibiotics have had a major impact on human health and molecular biology [1]. Beyond their efficacy against a variety of infectious diseases, insights into resistance and discovery of the tetracycline repressor system has yielded an invaluable tool for the inducible control of gene expression. Though originally characterized as selective inhibitors of the bacterial 30S ribosomal subunit [2], tetracyclines appear also to have alternate molecular targets in human tissues and are effective in treating certain skin disorders such as acne and rosacea, which extends beyond a direct antimicrobial effect [3]. Three separate recently published reports characterize “these off-target ” activities in detail, suggesting that doxycycline might be repurposed as an anti-cancer therapeutic.
Source: Oncotarget
Authors: David A. Barbie, Brian K. Kennedy
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1843537154