Maximum-likelihood estimation of phylogeny from DNA sequences when substitution rates differ over sites.
Year: 1993
Type: article
Abstract: Felsenstein's maximum-likelihood approach for inferring phylogeny from DNA sequences assumes that the rate of nucleotide substitution is constant over different nucleotide sites. This assumption is sometimes unrealistic, as has been revealed by analysis of real sequence data. In the present paper Felsenstein's method is extended to the case where substitution rates over sites are described by the gamma distribution. A numerical example is presented to show that the method fits the data better than do previous models.
Source: Molecular Biology and Evolution
Author: Z Yang
Institution: China Agricultural University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W1844951369