Work

Ruolo fisiopatologico dell'ipertrofia miocardica, della disfunzione microcircolatoria e dell'apoptosi miocardiocitaria nella stenosi valvolare aortica

Year: 2006

Type: article

Abstract: The burden of aortic stenosis is increasing steadily and, despite major advances in diagnosis and management, surgical valve replacement is still the only effective treatment. Most recently, experimental studies in animals and clinical studies in humans have shown that myocardial hypertrophy, microcirculatory dysfunction and cardiomyocyte apoptosis are among the central pathophysiologic mechanisms involved in the natural history of aortic stenosis, i.e. the passage from a compensated and hypertrophic heart to a dysfunctional heart prone to ischemia, arrhythmia and pump failure. This updated review emphasizes the promises of these new research avenues as well as their potential therapeutic applications.

Source: Giornale italiano di cardiologia

DOI: 10.1714/696.7996

Authors: Marzia Lotrionte, Leda Galiuto, Giuseppe G. L. Biondi-Zoccai, Antonio Abbate

Institutions: Università Cattolica del Sacro Cuore, IRCCS Policlinico San Donato, Virginia Commonwealth University, Virginia Commonwealth University Medical Center

Language: Italian

Topic: Cardiac Valve Diseases and Treatments

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7125700944