Genetic variation in Th1/Th2 pathway genes and risk of non‐Hodgkin lymphoma: a pooled analysis of three population‐based case‐control studies
Year: 2011
Type: article
Abstract: The balance between T-helper 1 (Th1) and T-helper 2 (Th2) activity is critical in lymphoid cell development and differentiation. Immune dysfunction underlies lymphomagenesis, so an alteration in the regulation of key Th1/Th2 cytokines may lead to the development of non-Hodgkin lymphoma (NHL). To study the impact of polymorphisms in Th1/Th2 cytokines on NHL risk, we analyzed 145 tag single nucleotide polymorphisms (SNPs) in 17 Th1/Th2 cytokine and related genes in three population-based case-control studies (1946 cases and 1808 controls). Logistic regression was used to compute odds ratios (OR) for NHL and four major NHL subtypes in relation to tag SNP genotypes and haplotypes. A gene-based analysis adjusting for the number of tag SNPs genotyped in each gene showed significant associations with risk of NHL combined and one or more NHL subtypes for Th1 (IL12A and IL12RB1) and Th2 (IL4, IL10RB, and IL18) genes. The strongest association was for rs485497 in IL12A, which plays a central role in bridging the cellular and humoral pathways of innate resistance and antigen-specific adaptive immune responses (allele risk OR= 1·17; P(trend)= 0·00099). This SNP was also associated specifically with risk of follicular lymphoma (allele risk OR= 1·26; P(trend)= 0·0012). These findings suggest that genetic variation in Th1/Th2 cytokine genes may contribute to lymphomagenesis.
Source: British Journal of Haematology
Authors: Qing Lan, Sophia S. Wang, Idan Menashe, Bruce Armstrong, Yawei Zhang, Patricia Hartge, Mark P. Purdue, Theodore R. Holford, Lindsay M. Morton, Anne Kricker, James R. Cerhan, Andrew Grulich, Wendy Cozen, Shelia H. Zahm, Meredith Yeager, Claire M. Vajdic, Maryjean Schenk, Brian Leaderer, Jeff Yuenger, Richard K. Severson, Nilanjan Chatterjee, Stephen J. Chanock, Tongzhang Zheng, Nathaniel Rothman
Institutions: United States Department of Health and Human Services, National Institutes of Health, National Cancer Institute, Division of Cancer Epidemiology and Genetics, City Of Hope National Medical Center, City of Hope, The University of Sydney, Yale University, Mayo Clinic, UNSW Sydney, University of Southern California, USC Norris Comprehensive Cancer Center, University of Washington, Fred Hutch Cancer Center, Wayne State University, The Barbara Ann Karmanos Cancer Institute
Language: English
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G1041864957, SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G1788914148, SURVEILLANCE, EPIDEMIOLOGY, AND END RESULTS--SEER, SURVEILLANCE EPIDEMIOLOGY &END RESULTS PROGRAM, G4836174358, G5185757912, G5372537626, HAIR DYE USE AND RISK OF NONHODGKINS LYMPHOMA, G835684289, G9000046702
OpenAlex ID: W1846877014