Work

High Mortality Risk in Chronic Kidney Disease and End Stage Kidney Disease Patients with Clostridium Difficile Infection: A Systematic Review and Meta-analysis.

Year: 2015

Type: review

Study designs: Systematic Review, Meta-Analysis

Abstract: BACKGROUND: infection (CDI). METHODS: A literature search was performed from inception through February 2015. Studies that reported relative risks, odds ratios, or hazard ratios comparing the mortality risk of CKD or ESRD patients with CDI versus those without CDI were included. Pooled risk ratios (RRs) and 95% confidence intervals (CIs) were calculated using a random-effect, generic inverse variance method. RESULTS: Four cohort studies with 8,214,676 patients were included in the meta-analysis. Pooled RR of mortality in CKD patients with CDI was 1.73 (95% CI 1.39-2.15). When meta-analysis was limited only to included studies with ESRD patients, the pooled RR of mortality in patients with ESRD was 2.15 (95% CI, 2.07-2.23). CONCLUSION: This meta-analysis demonstrates significantly increased risks of mortality in CKD and ESRD patients with CDI. The magnitudes of mortality risk are high.

Source: PubMed

Authors: Charat Thongprayoon, Wisit Cheungpasitporn, Parkpoom Phatharacharukul, Pailin Mahaparn, Jackrapong Bruminhent

Institutions: Mayo Clinic, University of Minnesota, Chulalongkorn University, Mahidol University, Ramathibodi Hospital

Language: English

Topic: Clostridium difficile and Clostridium perfringens research

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institutes of Health

Award: Mayo Clinic Center for Clinical and Translational Science (CCaTS)