Work

Adrenal Androgens and Androgen Precursors—Definition, Synthesis, Regulation and Physiologic Actions

Year: 2014

Type: other

Abstract: The human adrenal produces more 19 carbon (C19) steroids, by mass, than either glucocorticoids or mineralocorticoids. However, the mechanisms regulating adrenal C19 steroid biosynthesis continue to represent one of the most intriguing mysteries of endocrine physiology. This review will discuss the C19 steroids synthesized by the human adrenal and the features within the adrenal that allow production of these steroids. Finally, we consider the effects of these steroids in normal physiology and disorders of adrenal C19 steroid excess.

Source: Comprehensive physiology

DOI: 10.1002/cphy.c140006

Authors: Adina Turcu, Joshua M. Smith, Richard Auchus, William E. Rainey

Institutions: University of Michigan, Michigan Medicine, The University of Texas Southwestern Medical Center

Language: English

Topic: Adrenal Hormones and Disorders

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: National Institute of Diabetes and Digestive and Kidney Diseases