Work

Clinical studies linking fetal velocimetry, blood flow and placental transport in pregnancies complicated by intrauterine growth retardation (IUGR).

Year: 2003

Type: article

Abstract: Our research has focused on two aspects of IUGR pregnancies: first, the changes in the fetal circulation which progress to fetal circulatory failure, and second, to reduced placental transport for amino acid and carbohydrate. There are sequential changes in fetal velocimetry for 8 different velocimetric indices. Measurements of blood flows in the fetal ductus venosus and in the umbilical vein have identified a subset of IUGR fetuses with significantly reduced umbilical blood flow, increased ductal shunt and reduced hepatic flow. Studies of placental amino acid transport in vivo have shown differences between normal and IUGR pregnancies which can be related to the velocimetry data. Clinical severity in FGR pregnancies can be related to 2 different sets of metabolic data. One is that of the glucose gradients across the placenta and another is the fetal/maternal enrichment ratios for amino acids. The implication and extension of these studies will be discussed.

Source: Europe PMC (PubMed Central)

Author: Frederick C Battaglia

Institutions: University of Colorado Health, University of Colorado Anschutz

Language: English

Topic: Pregnancy and preeclampsia studies

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Eunice Kennedy Shriver National Institute of Child Health and Human Development

Award: Fetal Velocimetry & Amino Acid Transport in Pregnancy