Work

Mechanisms of disease: epithelial-mesenchymal transition and back again: does cellular plasticity fuel neoplastic progression?

Year: 2008

Type: article

Abstract: Epithelial-mesenchymal transition (EMT) is a conversion that facilitates organ morphogenesis and tissue remodeling in physiological processes such as embryonic development and wound healing.A similar phenotypic conversion is also detected in fibrotic diseases and neoplasia, which is associated with disease progression.EMT in cancer epithelial cells often seems to be an incomplete and bi-directional process.In this Review, we discuss the phenomenon of EMT as it pertains to tumor development, focusing on exceptions to the commonly held rule that EMT promotes invasion and metastasis.We also highlight the role of the RAS-controlled signaling mediators, ERK1, ERK2 and PI3-kinase, as microenvironmental responsive regulators of EMT.

Source: University of North Texas Digital Library (University of North Texas)

Authors: Mina J. Bissell, Eva A. Turley, Mandana Veiseh, Derek C. Radisky

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1853333923

FWCI:

Cites: 91

Cited by: 1

Related to: 20