Year: 2014
Type: editorial
Abstract: ‘Simplify your life. ’ In research- contrasting such a popular concept- we are challenged by an ever-expanding plethora of observations and accumulation of knowledge. This leads to the development of increasingly complex models trying to explain all aspects of our world that are subject to scientific endeavor. Recently, a well-known object of study from the life sciences, the tumor suppressor p53, has emerged as an example for which diversity of its apparent functions has actually decreased. p53 has long been described to function as a transcription factor. Initially, the cyclin-dependent kinase inhibitor gene CDKN1A (p21WAF1/CIP1) had been discovered as transcriptionally activated by p53 [1]. Similar to this early observation, many genes were detected to be activated by the tumor suppressor. Often the genes
Source: Oncotarget
Author: Kurt Engeland
Institution: Leipzig University
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W1853981280