Work

Neural substrates of cue reactivity: association with treatment outcomes and relapse

Year: 2015

Type: article

Abstract: Given the strong evidence for neurological alterations at the basis of drug dependence, functional magnetic resonance imaging (fMRI) represents an important tool in the clinical neuroscience of addiction. fMRI cue-reactivity paradigms represent an ideal platform to probe the involvement of neurobiological pathways subserving the reward/motivation system in addiction and potentially offer a translational mechanism by which interventions and behavioral predictions can be tested. Thus, this review summarizes the research that has applied fMRI cue-reactivity paradigms to the study of adult substance use disorder treatment responses. Studies utilizing fMRI cue-reactivity paradigms for the prediction of relapse and as a means to investigate psychosocial and pharmacological treatment effects on cue-elicited brain activation are presented within four primary categories of substances: alcohol, nicotine, cocaine and opioids. Lastly, suggestions for how to leverage fMRI technology to advance addiction science and treatment development are provided.

Source: Addiction Biology

DOI: 10.1111/adb.12314

Authors: Kelly E. Courtney, Joseph P. Schacht, Kent Hutchison, Daniel J. O. Roche, Lara A. Ray

Institutions: University of California, Los Angeles, Medical University of South Carolina, University of Colorado Boulder

Language: English

Topic: Substance Abuse Treatment and Outcomes

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institute on Alcohol Abuse and Alcoholism, National Institute on Drug Abuse