Work

Atypical antipsychotic drugs inhibit trabecular bone accrual in C57BL/6J mice.

Year: 2013

Type: article

Abstract: OBJECTIVE: To investigate the effects of the atypical antipsychotics drugs (AADs), olanzapine and risperidone, on femoral bone characteristics in female C57BL/6J mice. METHODS: Mice were treated with placebo or AADs (olanzapine or risperidone) for 3-4 weeks. Femoral cortical and trabecular bone characteristics were determined using micro-computed tomography. RESULTS: = 0.003) relative to controls. Cortical bone was not significantly affected by olanzapine or risperidone treatment. CONCLUSION: AADs inhibited trabecular bone accrual in C57BL/6J mice suggesting that alternative treatment options may need to be considered for the schizophrenia patient with potential osteoporosis risk.

Source: PubMed

Authors: Xingsheng Li, Tim R Nagy

Institution: University of Alabama at Birmingham

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Arthritis and Musculoskeletal and Skin Diseases

Awards: UAB Core Center for Basic Skeletal Research (CCBSR), UAB Diabetes Research and Training Center, Antipsychotic drug-induced weight gain, UAB Nutrition Obesity Research Center (NORC), UAB Diabetes Research Center