Marinobufagenin Induced Uremic Cardiomyopathy: The Role of Passive Immunization, Rapamycin, and CD40 Signaling in The Generation of Renal Fibrosis
Year: 2012
Type: article
Abstract: Chapter 1 -Literature Review and Introduction 1Chapter 2 -"Monoclonal antibody against marinobufagenin reverses cardiac fibrosis in rats with chronic renal failure" (Manuscript) 10 2.1 Abstract 11 expression of Fli-1, and caused a significant reduction in cardiac fibrosis.33 Spironolactone and its major metabolite have been shown to competitively inhibit CTS binding to the Na/K-ATPase.34 We have shown that spironolactone treatment in both PNx animals and animals receiving MBG infusion attenuated diastolic dysfunction and cardiac fibrosis in these experimental animal models.35 Our findings indicate that spironolactone and the 3E9 monoclonal antibody may offer potential indications for the treatment of uremic cardiomyopathy.17.
Author: Steven T. Haller
Institution: University of Toledo
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W185898409