Work

Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development

Year: 1996

Type: article

Abstract: Developmentally regulated delayed rectifier potassium currents determine the waveform of the action potential in all Xenopus embryonic primary spinal neurons. To examine this developmental program at the molecular level, we have isolated Xenopus Kv2 potassium channel genes Kv2.1 and Kv2.2. Both genes induce functional heterologous expression of delayed rectifier potassium currents. Transcripts from both Kv2 genes are present in developing embryos; however, only Kv2.2 mRNA is detectable in embryonic spinal neurons. Notably, Kv2.2 transcripts localize to ventral spinal neurons, whereas previously described Kv1.1 transcripts are found in dorsal spinal neurons. Thus, spinal neuron subtypes express distinct potassium channel genes, yet they temporally coordinate functional expression of delayed rectifier potassium currents.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.16-04-01412.1996

Authors: C Burger, AB Ribera

Institutions: University of Colorado Health, University of Colorado Denver

Language: English

Topic: Ion channel regulation and function

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Neurological Disorders and Stroke

Awards: POTASSIUM CURRENTS ROLE IN THE DEVELOPING NERVOUS SYSTEM, G3047538161, G4669088688