Year: 1984
Type: article
Abstract: The article "Maintenance Requirements of L-Thyroxine in the Treatment of Hypothyroidism" by W.A. Kehoe, B.J. Dong and F.S. Greenspan,' in the June 1984 issue, contains an addendum which has some incorrect state- ments that may be misleading to your readers.The addendum states that Synthroid tablets were reformu- lated in 1983.In fact, the reformulation took place in 1982.Flint Laboratories' studies show that the bioavailability of the reformulated tablets averages 74%, compared to 70% for the old formulation.The figures of 78% and 100% given in the addendum are actually those reported not for bioavaila- bility but for potency by Stoffer and Szpunar.2These potency estimates were, however, based on immunoassay, a tech- nique that has not been validated for measurement of tablet potency.When official USP methodology is used, the po- tency of Synthroid tablets has not changed with the reformu- lation.I hope this will clarify matters for your readers.
Source: PubMed Central
Author: D L Horwitz
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1862628258