Work

Synthesis and in vitro evaluation of 4-substituted furano[3,2-c] tetrahydroquinolines as potential anti-cancer agents

Year: 2015

Type: article

Abstract: A convenient and mild method for the synthesis of substituted furano [3,2-c]tetrahydroquinoline derivatives was developed, using the multi-component Povarov reaction. Of the synthesized tetrahydroquinoline derivatives, compound 10a displayed the greatest cellular proliferation inhibitory activities with IC50 values of 2.5-16.7 μmol/l. In addition, 10a induced murine C6 glioma cell apoptosis in a dose-dependent manner by up-regulating the expression of Bax, caspase-3, and caspase-9, and by down-regulating Bcl-2. Our findings suggest that these novel compounds have potential as therapeutic agents via inducing mitochondrial apoptosis.

Source: Journal of Enzyme Inhibition and Medicinal Chemistry

DOI: 10.3109/14756366.2015.1064120

Authors: Can Chen, Sarah Zingales, Ting Wang, Mingyong Yuan, Dan Wang, Lulu Cai, Qinglin Jiang

Institutions: Chengdu Medical College, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, First Affiliated Hospital of Chengdu Medical College, Chengdu Military General Hospital

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W1862755336

FWCI: 0.145

Cites: 22

Cited by: 14

Related to: 10