Work

Interactions between statins andPenicillium chrysogenumantifungal protein (PAF) to inhibit the germination of sporangiospores of different sensitiveZygomycetes

Year: 2007

Type: article

Abstract: This study reports on the antifungal activities of statins combined with an antifungal compound secreted by Penicillium chrysogenum, PAF. Several species belonging in the class Zygomycetes are considered to be agents of human or animal mycoses; other species have significance as postharvest plant pathogens. In the present work, four species (Rhizopus stolonifer, Mortierella wolfii, Syncephalastrum racemosum and Mycotypha africana) that exhibited different sensitivities to lovastatin and PAF in previous experiments were investigated. The efficiencies with which four statins (lovastatin, simvastatin, rosuvastatin and atorvastatin) inhibited sporangiospore germination in the absence or in the presence of a constant concentration of PAF were studied. PAF and lovastatin acted synergistically on the sporangiospore germination of Mycotypha africana, and similar effects of the combinations PAF-rosuvastatin and PAF-atorvastatin were observed on S. racemosum.

Source: FEMS Microbiology Letters

DOI: 10.1111/j.1574-6968.2007.00661.x

Authors: LÃ¡szlÃ³ GalgÃ³czy, TamÃ¡s Papp, GyÃ¶ngyi LukÃ¡cs, Ãva Leiter, IstvÃ¡n PÃ³csi, Csaba VÃ¡gvÃ¶lgyi

Institutions: University of Szeged, University of Debrecen

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funder: Core Research for Evolutional Science and Technology