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Tumor-Promoting Phorbol Esters Inhibit Procollagen Synthesis at a Pretranslational Level in JB-6 Mouse Epidermal Cells

Year: 1983

Type: article

Abstract: Collagen synthesis was inhibited in JB-6 mouse epidermal cells after exposure to 12-O-tetradecanoylphorbol-13-acetate under conditions leading to irreversible neoplastic transformation. In vitro translation and hybridization studies demonstrated a dramatic decrease in collagen mRNA in 12-O-tetradecanoylphorbol-13-acetate-treated cells, suggesting that the inhibition of collagen synthesis in response to 12-O-tetradecanoylphorbol-13-acetate is due to regulation at a pretranslational level.

Source: Molecular and Cellular Biology

DOI: 10.1128/mcb.3.8.1527

Authors: M E Sobel, L D Dion, J Vuust, N H Colburn

Language: English

Topic: Protein Kinase Regulation and GTPase Signaling

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1866867806

FWCI: 2.222

Cites: 38

Cited by: 35

Related to: 10