Work

Metastatic cancer stem cells: from the concept to therapeutics.

Year: 2014

Type: article

Abstract: Metastatic cancer stem cells (MCSCs) refer to a subpopulation of cancer cells with both stem cell properties and invasion capabilities that contribute to cancer metastasis. MCSCs have capability of self-renewal, potentials of multiple differentiation and development and/or reconstruction of cancer tissues. As compared with stationary cancer stem cells, MCSCs are capable of invasion to normal tissues such as vasculatures, resistance to chemo- and/or radio-therapies, escape from immune surveillance, survival in circulation and formation of metastasis. MCSCs are derived from invasive cancer stem cells (iCSCs) due to the plasticity of cancer stem cells, which is one of the characteristics of cancer cell heterogeneity. Both stages of iCSCs and MSCSs are the potential therapeutic targets for cancer metastasis in the future strategies of personalized cancer therapy.

Source: Europe PMC (PubMed Central)

Authors: Wen-Ting Liao, Ya-Ping Ye, Yong-Jian Deng, Xiu-Wu Bian, Yan-Qing Ding

Institutions: Southern Medical University, Army Medical University, Southwest Hospital

Language: English

Topic: Cancer Cells and Metastasis

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W1867045435

FWCI: 6.389

Cites: 169

Cited by: 91

Related to: 10