Year: 2007
Type: article
Abstract: 3-Hydroxypropionaldehyde (3-HPA) is of high industrial interest as a new platform intermediate from bioconversion of renewable materials because it can be converted into a number of large scale commodity chemicals.In this work we studied the production of 3-HPA from bioconversion of glycerol in a two-stage process.In the first stage active biomass is produced.The active biomass is then used for the production of 3-HPA in a second stage by biotransformation with the help of semicarbazide to trap 3-HPA from the culture.First we optimized the conditions for active biomass production for the biotransformation in the second step.By using a fed-batch process with proper feeding of semicarbazide and supplementary addition of active biomass we reached a final concentration of 54 g/l 3-HPA with a yield of 97 % (mol/mol).This represents the highest 3-HPA concentration and yield reported so far for the microbial production of 3-HPA from glycerol.
Authors: C. Ulmer, An‐Ping Zeng
Institution: Hamburg University of Technology
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W1868595871