Notice of Retraction and Replacement. Lopes et al. Gamma ventral capsulotomy for obsessive-compulsive disorder: a randomized clinical trial.JAMA Psychiatry. 2014;71(9):1066-1076
Year: 2015
Type: letter
Abstract: In Reply On behalf of our coauthors, we are grateful to Dr Baethge for his detailed reading of our study.He is correct that for the primary outcome, we inadvertently misclassified a patient (ATa3) as a responder when indeed that patient was a nonresponder.When preparing the table, we inadvertently included in our computation of treatment response a Yale-Brown Obsessive-Compulsive Scale (Y-BOCS) score of 36 (the patient's first measure) instead of 30 (the second measure).We defined the baseline Y-BOCS score for this study as the last value obtained before surgery.At that point, all patients knew they would receive the procedure.Thus, instead of 3 of 8 patients responding in the treatment group at 12 months, 2 of 8 responded compared with 0 of 8 in the control group.Because of this error, the analysis has been redone and we have requested that JAMA Psychiatry retract and replace the original article.In the corrected article, 1 corrections have been made to the Abstract; Results, Discussion, and Conclusions sections of the text; Tables 2 and3; Figure 2; and eFigure 3 and eTables 5, 6, and 7 in the Supplement.The article now concludes, "In this preliminary trial, patients with intractable OCD [obsessivecompulsive disorder] who underwent GVC [gamma ventral capsulotomy] may have benefitted more than those who un-derwent sham surgery although the difference did not reach statistical significance.Additional research is necessary to determine if GVC is better than deep-brain stimulation."We regret the errors caused by this misclassification as well as the confusion it caused for JAMA Psychiatry, readers, and potentially patients.
Source: JAMA Psychiatry
Institutions: Universidade de São Paulo, Brown University
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: bronze
OpenAlex ID: W1869478412