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Cancer stem cells in glioma: challenges and opportunities.

Year: 2013

Type: article

Abstract: The discovery of cancer stem cells in glioma has created a paradigm shift in our understanding of this deadly disease. Glioma stem cells exhibit sustained self-renewal and potent tumorigenic potential and differ from their more differentiated progeny in response to current therapies. Recurrent disease is likely derived from glioma stem cells or progeny reprogrammed to gain stem cell-like phenotypes, indicating that the stem cell phenotype is a crucial therapeutic target. While debate over cancer stem cell and clonal evolution models persists, important knowledge has been gained over the past decade from glioma stem cells investigation and clinical impact is expected.

Source: PubMed

DOI: 10.3978/j.issn.2218-676x.2013.08.01

Authors: Jialiang Wang, Yufang Ma, Michael K Cooper

Institutions: Vanderbilt University Medical Center, VA Tennessee Valley Healthcare System

Language: English

Topic: Glioma Diagnosis and Treatment

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Cancer Institute