Year: 2014
Type: dissertation
Abstract: FoxO transcription factors play important roles in many cellular processes, including regulation of lifespan in invertebrates and potentially in vertebrates.Our understanding of FoxO target genes that play a role in lifespan control is incomplete and C. elegans is a useful system in which to approach this problem since it has a single FoxO ortholog (DAF-16) and a relatively short lifespan.Using multiple unique genetic filters and RNA-sequencing, we have previously identified a list of 47 putative daf-16/FoxO target genes that are likely to play a role in lifespan extension.Y39G8B.7 is one of these genes and showed a significant shortening of lifespan in a long-lived background during a pilot lifespan assay.I have validated Y39G8B.7 as a bona fide daf-16/FoxO target gene and investigated its functional role in longevity.
Author: Ian Waters
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W187102521